N‐methoxy‐N‐methyl‐2‐phenyl butyramide

Base Information

• Chemical Name: N‐methoxy‐N‐methyl‐2‐phenyl butyramide
• CAS No.: 166337-42-4
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 166337-42-4.mol

Synonyms:N‐methoxy‐N‐methyl‐2‐phenyl butyramide

Chemical Property of N‐methoxy‐N‐methyl‐2‐phenyl butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N‐methoxy‐N‐methyl‐2‐phenyl butyramide

There total 5 articles about N‐methoxy‐N‐methyl‐2‐phenyl butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Phenylbutyryl chloride (36854-57-6) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N‐methoxy‐N‐methyl‐2‐phenyl butyramide (166337-42-4)

Guidance literature:

With pyridine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

Reference yield: 80.0%

methyl 2-phenylbutanoate (2294-71-5) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N‐methoxy‐N‐methyl‐2‐phenyl butyramide (166337-42-4)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

methyl 2-phenylbutanoate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1021/op4001548

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride (68641-49-6) + 2-Phenylbutyric acid (90-27-7) → N‐methoxy‐N‐methyl‐2‐phenyl butyramide (166337-42-4)

Guidance literature:

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In hexane; dichloromethane; ethyl acetate;

upstream raw materials:

2-Phenylbutyryl chloride

N,O-dimethylhydroxylamine*hydrochloride

bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

2-Phenylbutyric acid

Downstream raw materials:

1,2-diphenyl-butan-1-one