5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Base Information

Chemical Name:5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide
CAS No.:1285513-90-7
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

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Chemical Property of 5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Chemical Property:

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Technology Process of 5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

There total 7 articles about 5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285516-51-9
5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]benzoic acid

: 1285513-90-7
5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

: 636-46-4
4-hydroxyisophthalic acid

: 1285513-90-7
5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 50 °C

2: water; lithium hydroxide / tetrahydrofuran / 20 °C

3: sulfuric acid / 3 h / 20 °C

4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

5: dichloromethane / 2 h / 20 °C

6: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1285516-43-9
bis(phenylmethyl) 4-[(phenylmethyl)oxy]-1,3-benzenedicarboxylate

: 1285513-90-7
5-[(4-methyl-1-piperazinyl)carbonyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2: sulfuric acid / 3 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4: dichloromethane / 2 h / 20 °C

5: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sulfuric acid; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;