5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione

Base Information

• Chemical Name: 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione
• CAS No.: 1289425-18-8
• Molecular Formula: C₁₈H₁₆N₆OS₂
• Molecular Weight: 396.497

Synonyms:5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione

Chemical Property of 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione

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Technology Process of 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione

There total 5 articles about 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1289425-05-3) → 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione (1289425-18-8)

Guidance literature:

With sodium hydroxide; In water; for 2h; Reflux;

DOI:10.1002/jhet.563

Reference yield:

4-phenyl-Δ2-1,2,4-triazoline-5-thione (5373-72-8) → 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione (1289425-18-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 17 h / 25 °C / Reflux

2: hydrazine hydrate / ethanol / 24 h / 25 °C

3: 12 h / 50 °C

4: sodium hydroxide / water / 2 h / Reflux

With sodium ethanolate; hydrazine hydrate; sodium hydroxide; In ethanol; water;

DOI:10.1002/jhet.563

Reference yield:

[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide (59909-04-5) → 5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione (1289425-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / 50 °C

2: sodium hydroxide / water / 2 h / Reflux

With sodium hydroxide; In water;

DOI:10.1002/jhet.563

upstream raw materials:

1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

4-phenyl-Δ²-1,2,4-triazoline-5-thione

[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide

ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate

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