1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Base Information

• Chemical Name: 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide
• CAS No.: 1289425-05-3
• Molecular Formula: C₁₈H₁₈N₆O₂S₂
• Molecular Weight: 414.512
• Mol file: 1289425-05-3.mol

Synonyms:1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Chemical Property of 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide

There total 3 articles about 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenyl-Δ2-1,2,4-triazoline-5-thione (5373-72-8) → 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1289425-05-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 17 h / 25 °C / Reflux

2: hydrazine hydrate / ethanol / 24 h / 25 °C

3: 12 h / 50 °C

With sodium ethanolate; hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.563

Reference yield:

1-formyl-4-phenyl-3-thiosemicarbazide → 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1289425-05-3)

Guidance literature:

Multi-step reaction with 4 steps

1: Alkaline conditions

2: sodium ethanolate / ethanol / 17 h / 25 °C / Reflux

3: hydrazine hydrate / ethanol / 24 h / 25 °C

4: 12 h / 50 °C

With sodium ethanolate; hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.563

Reference yield:

ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate (84210-48-0) → 1-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}-4-(4-methoxyphenyl)thiosemicarbazide (1289425-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 24 h / 25 °C

2: 12 h / 50 °C

With hydrazine hydrate; In ethanol;

DOI:10.1002/jhet.563

upstream raw materials:

4-phenyl-Δ²-1,2,4-triazoline-5-thione

ethyl [(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate

Downstream raw materials:

5-{[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-4-(4-methoxyphenyl)-4H-1,2,4-triazole-3(2H)-thione