di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Base Information

Chemical Name:di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate
CAS No.:671246-46-1
Molecular Formula:C₃₂H₅₀N₂O₉
Molecular Weight:606.757
Hs Code.:

Synonyms:di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

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Chemical Property of di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Chemical Property:

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Technology Process of di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

There total 1 articles about di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 136586-99-7
4-amino-4-(2-tert-butoxycarbonylethyl)heptanedioic acid di-tertbutyl ester

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 671246-46-1
di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Inert atmosphere;
DOI:10.1021/jo102185d

Reference yield: 95.0%

: 671246-46-1
di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

: 671246-47-2
4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(2-carboxyethyl)heptanedioic acid

Guidance literature:: di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate; With water; trifluoroacetic acid; In dichloromethane; at -10 - 20 ℃; for 1.5h;

With sodium hydroxide; water; In dichloromethane; pH=5;

With hydrogenchloride; In dichloromethane; water; pH=2;

Reference yield:

: 671246-46-1
di-tert-butyl 4-(2-(((benzyloxy)carbonyl)amino)acetamido)-4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate

: 1274686-40-6
4-(Z-N-2-aminoethanamido)-N₁,N₇-bis[2-(2-acetoxyethoxy)ethyl]-4-{3-[2-(2-acetoxyethoxy)ethylamino]-3-oxopropyl}heptanediamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo102185d