3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile

Base Information

• Chemical Name: 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile
• CAS No.: 877222-08-7
• Molecular Formula: C₁₆H₁₁N₃S₃
• Molecular Weight: 341.481

Synonyms:3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile

Chemical Property of 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile

There total 2 articles about 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-[4-(2-thienyl)-1,3-thiazol-2-yl]ethanenitrile (351443-25-9) + phenyl isothiocyanate (103-72-0) → 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile (877222-08-7)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1080/104265090885048

Reference yield:

2-Bromoacetylthiophene (10531-41-6) → 3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile (877222-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ethanol / 2 h / Heating

2: 65 percent / potassium hydroxide / dimethylformamide / 20 °C

With potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1080/104265090885048

Reference yield: 82.0%

3-(phenylamino)-2-[4-(2-thienyl)-1,3-thiazol-2-yl]-3-thioxopropanenitrile (877222-08-7) → 5-[1-Cyano-1-(4-thiophen-2-yl-thiazol-2-yl)-meth-(E)-ylidene]-4-p-tolyl-4,5-dihydro-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester

Guidance literature:

In N,N-dimethyl-formamide; for 3h;

DOI:10.1080/104265090885048

upstream raw materials:

2-[4-(2-thienyl)-1,3-thiazol-2-yl]ethanenitrile

phenyl isothiocyanate

2-Bromoacetylthiophene

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