2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride

Base Information

• Chemical Name: 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride
• CAS No.: 118698-60-5
• Molecular Formula: C₁₆H₁₄ClN₃O₂*ClH
• Molecular Weight: 352.22
• Mol file: 118698-60-5.mol

Synonyms:2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride

Chemical Property of 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride

There total 1 articles about 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine (952-13-6) + ethyl bromoacetate (105-36-2) → 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride (118698-60-5)

Guidance literature:

In N-methyl-acetamide; ethyl acetate;

Reference yield: 95.0%

2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride (118698-60-5) → 2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid (118696-15-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 2.5h; Heating;

DOI:10.1021/jm00114a007

Reference yield:

2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid ethyl ester monohydrochloride (118698-60-5) → 2-(4-chlorophenyl)-N,N-dipropyl-1H-imidazo[4,5-b]pyridine-1-acetamide (118697-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq.KOH / ethanol / 2.5 h / Heating

2: 1.) 1,1'-carbonyldiimidazole / 1.) THF, RT, 3 h, 2.) THF, RT, overnight

With potassium hydroxide; 1,1'-carbonyldiimidazole; In ethanol;

DOI:10.1021/jm00114a007

upstream raw materials:

2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine

ethyl bromoacetate

Downstream raw materials:

2-(4-chlorophenyl)-1H-imidazo<4,5-b>pyridine-1-acetic acid

2-(4-chlorophenyl)-N,N-dipropyl-1H-imidazo[4,5-b]pyridine-1-acetamide