4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Base Information

Chemical Name:4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid
CAS No.:289059-56-9
Molecular Formula:C₁₂H₇F₅N₂O₃
Molecular Weight:322.191
Hs Code.:

Synonyms:4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

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Chemical Property of 4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Chemical Property:

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Technology Process of 4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

There total 2 articles about 4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83643-84-9,488711-09-7
methyl 4,4,4-trifluoroacetoacetate

: 34036-07-2
3,4 difluorobenzaldehyde

: 57-13-6
urea

: 4-(+)-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester

: 289059-56-9
4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Guidance literature:: methyl 4,4,4-trifluoroacetoacetate; 3,4 difluorobenzaldehyde; urea; With boron trifluoride diethyl etherate; acetic acid; copper(II) oxide; In tetrahydrofuran; Heating;

With subtilistin enzyme; In water; acetonitrile; at 23 ℃; for 24h; Further stages.;
DOI:10.1021/jm990612y

Reference yield:

: 83643-84-9,488711-09-7
methyl 4,4,4-trifluoroacetoacetate

: 34036-07-2
3,4 difluorobenzaldehyde

: 57-13-6
urea

: 4-(+)-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester

: 289059-56-9
4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

: (S)-4-(3,4-Difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid

Guidance literature:: methyl 4,4,4-trifluoroacetoacetate; 3,4 difluorobenzaldehyde; urea; With boron trifluoride diethyl etherate; acetic acid; copper(II) oxide; In tetrahydrofuran; Heating;

With subtilistin enzyme; In water; acetonitrile; at 37 ℃; for 48h; Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jm990612y

Reference yield:

: 189129-78-0
3-[4-(pyridin-2-yl)-piperidine-1-yl]propylamine

: 289059-56-9
4-(3,4-difluorophenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

: 4-(3,4-difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid [3-(3',4',5',6'-tetrahydro-2'H-[2,4']bipyridinyl-1'-yl)-propyl]-amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm990612y