1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

Base Information

Chemical Name:1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol
CAS No.:1117903-19-1
Molecular Formula:C₁₈H₁₉FN₂O₅
Molecular Weight:362.358
Hs Code.:

Synonyms:1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

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Chemical Property of 1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

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Technology Process of 1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

There total 5 articles about 1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

: 1117903-18-0
1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-mannitol

: 1117903-19-1
1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: With Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 30 ℃; for 42h;

Reference yield:

: 401906-49-8
1,5-anhydro-4,6-O-benzylidene-2-deoxy-2-(thymin-1-yl)-D-altro-hexitol

: 1117903-19-1
1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 3 h / 65 °C

3: Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / 42 h / 35 °C

With pyridine; Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja207086x

Reference yield:

: 1117903-17-9
1,5-anhydro-4,6-O-benzylidene-2-deoxy-3-O-methanesulfonyl-2-(thymin-1-yl)-D-altritol

: 1117903-19-1
1,5-anhydro-4,6-O-benzylidene-2,3-dideoxy-3-fluoro-2-(thymin-1-yl)-D-altritol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 3 h / 65 °C

2: Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene / 42 h / 35 °C

With Nonafluorobutanesulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In 1,4-dioxane;
DOI:10.1021/ja207086x