N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide

Base Information

• Chemical Name: N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide
• CAS No.: 119908-37-1
• Molecular Formula: C₂₀H₂₂N₂O₂
• Molecular Weight: 322.407
• Mol file: 119908-37-1.mol

Synonyms:N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide

Chemical Property of N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide

There total 1 articles about N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

bis<(S)-1-phenylethyl>carbodiimide (57122-22-2) + acrylic acid (79-10-7) → N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide (119908-37-1)

Guidance literature:

With triethylamine; In acetonitrile; for 24h; Ambient temperature;

DOI:10.1021/jo00271a036

Reference yield: 29.0%

N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide (119908-37-1) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → 1-((1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (119945-16-3) + 1-((1S,2R,4S)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (119945-15-2) + 1-((1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (119945-17-4) + 1-((1R,2S,4R)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea (119908-39-3)

Guidance literature:

In toluene; at 100 ℃; for 3h; Yields of byproduct given;

DOI:10.1021/jo00271a036

Reference yield:

N-((S)-1-phenylethyl)-N-((((S)-1-phenylethyl)amino)carbonyl)acrylamide (119908-37-1) → N,N'-bis<(S)-1-phenylethyl>carbodiimide (19035-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄, EtCl / 1 h / -115 °C

2: methanol / 8 h / 0 °C

With chloroethane; titanium tetrachloride; In methanol;

DOI:10.1246/cl.1988.1623

upstream raw materials:

bis<(S)-1-phenylethyl>carbodiimide

acrylic acid

Downstream raw materials:

1-(3-Chloro-propionyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea

(2R,3S)-2,3-Dimethyl-4-oxo-2-phenyl-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide

(2R,3R)-2,3-Dimethyl-4-oxo-2-phenyl-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide

1-((1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carbonyl)-1,3-bis-((S)-1-phenyl-ethyl)-urea