2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline

Base Information

• Chemical Name: 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline
• CAS No.: 75934-03-1
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 75934-03-1.mol

Synonyms:2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline

Chemical Property of 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline

There total 6 articles about 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline (75934-03-1)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 60 h

2: sodium hydride / 1) 20 min at 0 deg C 2) reflux for 12 h

3: sodium hydroxide / 1) 1h reflux with NaOH 2) concentrated HCl

4: thionyl chloride

5: dimethylsulfide; ozone / 1) 3 in MeOH at -78 deg C 2) room temperature overnight

With sodium hydroxide; thionyl chloride; dimethylsulfide; sodium hydride; potassium carbonate; ozone; In acetone;

DOI:10.1021/jo00317a027

Reference yield:

2-(3-allyl-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole (75934-02-0) → 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline (75934-03-1)

Guidance literature:

With dimethylsulfide; ozone; Yield given. Multistep reaction; 1) 3 in MeOH at -78 deg C 2) room temperature overnight;

DOI:10.1021/jo00317a027

Reference yield:

2-Allyl-6-(carbomethoxy)anisole (75934-00-8) → 2-<2-Methoxy-2-(formylmethyl)phenyl>-4,4-dimethyl-2-oxazoline (75934-03-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 1) 1h reflux with NaOH 2) concentrated HCl

2: thionyl chloride

3: dimethylsulfide; ozone / 1) 3 in MeOH at -78 deg C 2) room temperature overnight

With sodium hydroxide; thionyl chloride; dimethylsulfide; ozone;

DOI:10.1021/jo00317a027

upstream raw materials:

2-(3-allyl-2-methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole

methyl 2-allyloxybenzoate

2-Methoxy-3-allylbenzoic Acid

2-Allyl-6-(carbomethoxy)anisole

Downstream raw materials:

2,3-dihydrobenzofuran-7-carboxylic acid

2-[3-(2-Methanesulfonyl-ethyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

2-{2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethyl}-isoindole-1,3-dione

2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethylamine