9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

Base Information

Chemical Name:9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine
CAS No.:241824-53-3
Molecular Formula:C₃₀H₄₉N₅O₃SSi₂
Molecular Weight:615.988
Hs Code.:

9-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9<i>H</i>-purin-2-ylamine

Synonyms:9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

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Chemical Property of 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

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Technology Process of 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

There total 1 articles about 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 108-98-5
thiophenol

: 188823-57-6
2-amino-9-(3',5'-di-O-tert-butyldimethylsilyl-2'-deoxy-β-D-ribofuranosyl)-6-vinylpurine

: 241824-53-3
9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/ja990356e

Reference yield: 78.0%

: 701-99-5
Phenoxyacetyl chloride

: 241824-53-3
9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

: 241824-52-2
N-[9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-yl]-2-phenoxy-acetamide

Guidance literature:: With benzotriazol-1-ol;
DOI:10.1021/ja990356e

Reference yield:

: 241824-53-3
9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-(2-phenylsulfanyl-ethyl)-9H-purin-2-ylamine

: Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(2-phenoxy-acetylamino)-6-(2-phenylsulfanyl-ethyl)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / 1-hydroxybenzotriazole

2: 76 percent / nBu₄NF

3: 75 percent / pyridine

4: 64 percent / iPr₂NEt / CH₂Cl₂

With pyridine; tetrabutyl ammonium fluoride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja990356e