1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Base Information

Chemical Name:1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one
CAS No.:639087-09-5
Molecular Formula:C₄₃H₇₆O₇S₂Si₂
Molecular Weight:825.375
Hs Code.:

1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Synonyms:1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Suppliers and Price of 1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

There total 20 articles about 1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 109-80-8
1.3-propanedithiol

: 639087-11-9
(6S,9R)-1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-9-methyl-8-methylene-6,10-bis(triethylsilanyloxy)dec-3-yn-2-one

: 639087-09-5
1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Guidance literature:: With sodium methylate; In methanol; dichloromethane; at -10 ℃;
DOI:10.1021/ol035849+

Reference yield:

: 994-30-9
triethylsilyl chloride

: 639087-09-5
1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / imidazole / tetrahydrofuran / 0.75 h / 20 °C

2.1: i-PrMgCl / tetrahydrofuran / 1.5 h / 0 °C

2.2: 77 percent / tetrahydrofuran / 1 h / -10 °C

3.1: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 3.25 h / 20 °C

4.1: 81 percent / NaOMe / methanol; CH₂Cl₂ / -10 °C

With 1H-imidazole; isopropylmagnesium chloride; sodium methylate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol035849+

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 639087-09-5
1-{(4S,6S)-6-[2-(p-methoxybenzyloxy)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}-3-[2-[(2S,5R)-5-methyl-4-methylene-2,6-bis(triethylsilanyloxy)hexyl][1,3]dithian-2-yl]propan-2-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: 94 percent / NaH; TBAI / tetrahydrofuran; dimethylformamide / 12.5 h / 20 °C

2.1: 78 percent / TsOH*H₂O / methanol / 18 h / 20 °C

3.1: 53 percent / NaH; triisopropylbenzylsulfonylimidazole / tetrahydrofuran; dimethylformamide / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / 20 °C

4.2: 72 percent / tetrahydrofuran; hexane / -20 - -10 °C

5.1: iodine; aq. NaHCO₃ / acetonitrile / 0.83 h / 0 - 20 °C

6.1: Et₂B(OMe); NaBH₄ / tetrahydrofuran; methanol / 12 h / -78 °C

7.1: 6.02 g / para-toluenesulfonic acid monohydrate / acetone / 1 h / 0 °C

8.1: 75 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

9.1: 85 percent / oxalyl chloride; DMSO; TEA / CH₂Cl₂ / -78 - 0 °C

10.1: i-PrMgCl / tetrahydrofuran / 1.5 h / 0 °C

10.2: 77 percent / tetrahydrofuran / 1 h / -10 °C

11.1: 90 percent / Dess-Martin periodinane / CH₂Cl₂ / 3.25 h / 20 °C

12.1: 81 percent / NaOMe / methanol; CH₂Cl₂ / -10 °C

With sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; triisopropylbenzylsulfonylimidazole; TEA; diethyl methoxy borane; tetrabutyl ammonium fluoride; iodine; isopropylmagnesium chloride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ol035849+