2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine

Base Information

• Chemical Name: 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine
• CAS No.: 1026325-96-1
• Molecular Formula: C₁₉H₂₂N₂O₄S
• Molecular Weight: 374.461
• Mol file: 1026325-96-1.mol

Synonyms:2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine

Chemical Property of 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine

There total 7 articles about 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,7-dimethoxy-3-(2-nitro-vinyl)-1-(toluene-4-sulfonyl)-1H-indole (892111-68-1) → 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine (1026325-96-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/jm051247f

Reference yield:

4,7-dimethoxylindole (23876-39-3) → 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine (1026325-96-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: POCl₃ / 1.5 h / 0 °C

2.1: ammonium acetate; acetic acid / 3 h / Heating

3.1: KOH / tetrahydrofuran / 0.08 h / 0 °C

3.2: 54 percent / tetrahydrofuran / 1 h / 20 °C

4.1: LiAlH₄ / diethyl ether; CH₂Cl₂ / 0.25 h / 0 °C

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; acetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jm051247f

Reference yield:

Dibenzyl-{2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl}-amine (220034-56-0) → 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine (1026325-96-1)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol;

DOI:10.1021/jo9815397

upstream raw materials:

Dibenzyl-{2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl}-amine

4,7-dimethoxy-3-(2-nitro-vinyl)-1-(toluene-4-sulfonyl)-1H-indole

4,7-dimethoxy-3-(2-nitro-vinyl)-1H-indole

4,7-dimethoxylindole

Downstream raw materials:

tert-butyl (2-{1-[(4-methylphenyl)sulfonyl]-4,7-dioxo-4,7-dihydro-1H-indol-3-yl}ethyl)carbamate

tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-7-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indazol-5-yl}ethyl)carbamate

tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,5,8-tetrahydro-pyrrolo[2,3-f]indazol-7-yl}ethyl)carbamate

7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one