isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate
CAS No.:1104442-28-5
Molecular Formula:C₂₂H₂₈N₂O₆S
Molecular Weight:448.54
Hs Code.:

Synonyms:isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

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Chemical Property of isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

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Technology Process of isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

There total 7 articles about isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₁₉H₂₂N₂O₆S

: 108-23-6
isopropyl chloroformate

: 1104442-28-5
isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; toluene; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm501175v

Reference yield:

: 53937-02-3
4-(benzyloxy)pyridin-2(1H)-one

: 1104442-28-5
isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 4 h / 145 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h / 760.05 Torr / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

5: triethylamine / dichloromethane; toluene / 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm501175v

Reference yield:

: 3466-32-8
4-bromoohenyl methyl sulfone

: 1104442-28-5
isopropyl 4-((1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; 8-quinolinol; potassium carbonate / dimethyl sulfoxide / 4 h / 145 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1.5 h / 760.05 Torr / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

5: triethylamine / dichloromethane; toluene / 1 h / 20 °C / Inert atmosphere

With copper(l) iodide; 8-quinolinol; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm501175v