2-bromo-4,5-difluorophenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate
• CAS No.: 236387-37-4
• Molecular Formula: C₇H₂BrF₅O₃S
• Molecular Weight: 341.053
• Mol file: 236387-37-4.mol

Synonyms:2-bromo-4,5-difluorophenyl trifluoromethanesulfonate

Chemical Property of 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate

There total 1 articles about 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-bromo-4,5-difluorophenol (166281-37-4) → 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate (236387-37-4)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1039/b701517h

Reference yield: 85.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + ethanol (64-17-5) + 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate (236387-37-4) → ethyl 2-bromo-4,5-difluorobenzoate (144267-97-0)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; at 20 ℃; for 16h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201600736

Reference yield: 50.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-4,5-difluorophenyl trifluoromethanesulfonate (236387-37-4) → 4-(2-chloro-4,5-difluorophenyl)morpholine

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; at 80 ℃; for 22h;

DOI:10.1039/b701517h

upstream raw materials:

trifluoromethylsulfonic anhydride

2-bromo-4,5-difluorophenol

Downstream raw materials:

[BrPd(P(C₆H₅)3)2(C₆H₂(F₂)OS(O₂)CF₃)]

ethyl 2-bromo-4,5-difluorobenzoate