1--4--2-butanone

Base Information

Chemical Name:1--4--2-butanone
CAS No.:78520-78-2
Molecular Formula:C₂₄H₃₁N₇O₉
Molecular Weight:561.552
Hs Code.:

1-<N-(2,4-diamino-5-nitropyrimidin-6-yl)amino>-4-<diethyl N-p-anisoyl-L-glutamate>-2-butanone

Synonyms:1--4--2-butanone

Suppliers and Price of 1--4--2-butanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1--4--2-butanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1--4--2-butanone

There total 8 articles about 1--4--2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

: (S)-2-[4-(2-{2-[(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-methyl]-[1,3]dioxolan-2-yl}-ethoxy)-benzoylamino]-pentanedioic acid diethyl ester

: 78520-78-2
1--4--2-butanone

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; at 55 ℃;
DOI:10.1021/jm00141a010

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 78520-78-2
1--4--2-butanone

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

2: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

3: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

4: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00141a010

Reference yield:

: 78520-73-7
1-azido-4--2-butanone

: 78520-78-2
1--4--2-butanone

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

2: 93.5 percent / 0.5 N NaOH / acetonitrile / 18 h / Ambient temperature

3: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

4: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

5: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

6: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; acetonitrile; benzene;
DOI:10.1021/jm00141a010