{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

Base Information

Chemical Name:{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester
CAS No.:882435-39-4
Molecular Formula:C₁₅H₂₂BrN₃O₃
Molecular Weight:372.262
Hs Code.:

Synonyms:{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

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Chemical Property of {(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

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Technology Process of {(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

There total 1 articles about {(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 51859-95-1
3-bromobenzylhydrazine

: 162537-11-3
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid

: 882435-39-4
{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; at 20 ℃;
DOI:10.1021/jm051239z

Reference yield: 46.0%

: 872703-72-5
(2S)-2-benzyl-oxirane-N-[(1S,2R)-2-hydroxy-indan-1-yl]-2-carboxylic acid amide

: 882435-39-4
{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

: 882435-40-7
{(1S)-1-[N'-(3-bromo-benzyl)-N'-[(2S)-2-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-phenyl-propyl]-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Guidance literature:: With titanium(IV) isopropylate; In tetrahydrofuran; at 40 ℃; for 2h;
DOI:10.1021/jm051239z

Reference yield:

: 882435-39-4
{(1S)-1-[N'-(3-bromo-benzyl)hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester

: {(S)-1-[N'-[(S)-2-Hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-3-phenyl-propyl]-N'-(3-pyridin-4-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / Ti(O-iPr)4 / tetrahydrofuran / 2 h / 40 °C

2: 31 percent / Pd(PPh₃)2Cl₂; aq. Na₂CO₃ / ethanol; 1,2-dimethoxy-ethane / 0.5 h / 120 °C / microwave irradiation

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; 2: Suzuki reaction;
DOI:10.1021/jm051239z