2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester
CAS No.:194146-48-0
Molecular Formula:C₃₄H₅₃NO₇Si
Molecular Weight:615.883
Hs Code.:

2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

Synonyms:2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 107-30-2
chloromethyl methyl ether

: 243662-98-8
5-amino-1-O-tert-butyldimethylsilyl-N-diphenylmethylene-4-O-pivaloyl-5-deoxy-L-galactitol

: 194146-48-0
2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

Guidance literature:: With N,N-diethyl-N-isopropylamine; In dichloromethane;
DOI:10.1021/jo9820115

Reference yield:

: 3282-30-2
pivaloyl chloride

: 194146-48-0
2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / 4-(dimethylamino)pyridine; pyridine / 48 h

2.1: K₃Fe(CN)6; K₂CO₃; CH₃SO₂NH₂ / K₂OsO₂(OH)4 / H₂O; 2-methyl-propan-2-ol / 20 °C

2.2: 50 percent / Na₂SO₃ / 2-methyl-propan-2-ol; H₂O / 0.33 h

3.1: 50 percent / iPrNEt₂ / CH₂Cl₂

With pyridine; dmap; N,N-diethyl-N-isopropylamine; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); potassium dioxotetrahydroxoosmate(VI); In dichloromethane; water; tert-butyl alcohol; 1.1: Acylation / 2.1: osmylation / 2.2: Hydrolysis / 3.1: Alkylation;
DOI:10.1021/jo9820115

Reference yield:

: 194146-32-2
(4S,5S,2E)-5-amino-N-diphenylmethylene-1-O-tert-butyldimethylsilyl-2-hexen-1,4-diol

: 194146-48-0
2,2-Dimethyl-propionic acid (1R,2R,3R)-1-[(S)-1-(benzhydrylidene-amino)-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,3-bis-methoxymethoxy-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / 4-(dimethylamino)pyridine; pyridine / 48 h

2.1: K₃Fe(CN)6; K₂CO₃; CH₃SO₂NH₂ / K₂OsO₂(OH)4 / H₂O; 2-methyl-propan-2-ol / 20 °C

2.2: 50 percent / Na₂SO₃ / 2-methyl-propan-2-ol; H₂O / 0.33 h

3.1: 50 percent / iPrNEt₂ / CH₂Cl₂

With pyridine; dmap; N,N-diethyl-N-isopropylamine; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); potassium dioxotetrahydroxoosmate(VI); In dichloromethane; water; tert-butyl alcohol; 1.1: Acylation / 2.1: osmylation / 2.2: Hydrolysis / 3.1: Alkylation;
DOI:10.1021/jo9820115