(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:192060-42-7
Molecular Formula:C₁₆H₂₃NO₂
Molecular Weight:261.364
Hs Code.:

Synonyms:(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Chemical Property:

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Technology Process of (R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 5 articles about (R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 556-56-9
allyl iodid

: 69856-85-5,69856-87-7
N-((R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide

: 192060-42-7
(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/ja970402f

Reference yield: 67.0%

: 106-95-6
allyl bromide

: 192060-67-6
(1R,2R)-(-)-pseudoephedrinepropionamide

: 192060-42-7
(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: (1R,2R)-(-)-pseudoephedrinepropionamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;

allyl bromide; In tetrahydrofuran; at -78 ℃; for 1h; Reagent/catalyst; Temperature; Time;
DOI:10.1021/jacs.9b00328

Reference yield:

: 637767-50-1
pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide

: 74-88-4
methyl iodide

: 192060-42-7
(R)-2-Methyl-pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: pent-4-enoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenylethyl)-methylamide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ja048170p