Technology Process of apoptozole
There total 3 articles about apoptozole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C117H124BF6N9O32; C57H79N13O14S2;
With
copper(ll) sulfate pentahydrate; sodium L-ascorbate; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol;
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
at 20 ℃;
for 4h;
With
dihydrogen peroxide;
In
water; dimethyl sulfoxide;
at 37 ℃;
for 12h;
With
ethylenediaminetetraacetic acid; cathepsin B from bovine spleen; sodium acetate; Cleland's reagent;
In
water; dimethyl sulfoxide;
at 37 ℃;
for 2h;
pH=5;
Enzymatic reaction;
DOI:10.1039/d1ob01089a
- Guidance literature:
-
C8H17N2O4Pol; 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid;
With
N-ethylmorpholine;; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
for 12h;
Wang resin
With
N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid; trifluoroacetic acid;
for 1h;
- Guidance literature:
-
C117H124BF6N9O32; C57H79N13O14S2;
With
copper(ll) sulfate pentahydrate; sodium L-ascorbate; 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol;
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
at 20 ℃;
for 4h;
With
dihydrogen peroxide;
In
water; dimethyl sulfoxide;
at 37 ℃;
for 12h;
Reagent/catalyst;
DOI:10.1039/d1ob01089a
