4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid

Base Information

• Chemical Name: 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid
• CAS No.: 1054543-79-1
• Molecular Formula: C₃₃H₂₄F₆N₂O₄
• Molecular Weight: 626.555
• Mol file: 1054543-79-1.mol

Synonyms:4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid

Chemical Property of 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid

There total 1 articles about 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

p-aminomethylbenzoic acid (56-91-7) + 3,5-Bis(trifluoromethyl)benzaldehyde (401-95-6) + 1,2-bis(4-methoxyphenyl)-1,2-ethanedione (1226-42-2) → 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid (1054543-79-1)

Guidance literature:

With ammonium acetate; acetic acid; at 100 ℃; for 12h;

DOI:10.1016/j.chembiol.2018.06.010

Reference yield: 88.0%

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid (1054543-79-1) + 11-amino-3,6,9-trioxaundecanol (86770-74-3) → C41H41F6N3O7

Guidance literature:

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

11-amino-3,6,9-trioxaundecanol; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.chembiol.2018.06.010

Reference yield: 80.0%

4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzoic acid (1054543-79-1) + 2-methoxyethylamine (109-85-3) → 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)-N-(2-methoxyethyl)benzamide

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

upstream raw materials:

p-aminomethylbenzoic acid

3,5-Bis(trifluoromethyl)benzaldehyde

1,2-bis(4-methoxyphenyl)-1,2-ethanedione

Downstream raw materials:

apoptozole