N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

Base Information

Chemical Name:N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine
CAS No.:1007308-68-0
Molecular Formula:C₁₇H₁₇ClN₄O₂
Molecular Weight:344.801
Hs Code.:

N<sub>4</sub>-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

Synonyms:N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

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Chemical Property of N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

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Technology Process of N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

There total 4 articles about N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 1007308-60-2
N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine

: 1007308-68-0
N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

Guidance literature:: With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol; at 20 ℃; for 3h;

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 1007308-68-0
N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / 17 h / 20 °C / Heating / reflux

2: triethylamine / N,N-dimethyl-formamide / isopropyl alcohol / 17 h / 20 °C

3: methanol / 16 h / Heating / reflux

4: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 3 h / 20 °C

With thionyl chloride; hydrogen; potassium carbonate; triethylamine; platinum(IV) oxide; N,N-dimethyl-formamide; In methanol; isopropyl alcohol;

Reference yield:

: 1007308-59-9
C₁₆H₁₂Cl₂N₄O₃

: 1007308-68-0
N₄-(3-chloro-4-methoxy-benzyl)-(7-methoxy-6-amino-quinazolin-4-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 16 h / Heating / reflux

2: hydrogen; potassium carbonate / platinum(IV) oxide / methanol / 3 h / 20 °C

With hydrogen; potassium carbonate; platinum(IV) oxide; In methanol;