(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea

Base Information

• Chemical Name: (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea
• CAS No.: 1450733-57-9
• Molecular Formula: C₂₄H₃₀N₄O₃
• Molecular Weight: 422.527
• Mol file: 1450733-57-9.mol

Synonyms:(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea

Chemical Property of (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea

There total 9 articles about (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea (1450733-46-6) → (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea (1450733-57-9)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.06.018

Reference yield:

(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester (1450733-36-4) → (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea (1450733-57-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: piperidine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

6.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

With piperidine; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; triethylamine; sodium iodide; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2013.06.018

Reference yield:

(S)-1-benzyl-3-(1-(4-nitrobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea (1450733-42-2) → (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea (1450733-57-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; triethylamine; sodium iodide; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2013.06.018

upstream raw materials:

(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

(S)-1-(p-nitrobenzyl)-2,2-dimethoxyethan-1-amine

benzaldehyde

1-Aminopiperidine