(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Base Information

Chemical Name:(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea
CAS No.:1450733-46-6
Molecular Formula:C₂₆H₃₆N₄O₄
Molecular Weight:468.596
Hs Code.:

Synonyms:(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

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Technology Process of (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

There total 8 articles about (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1450733-45-5
(S)-1-benzyl-3-(1-(4-aminobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

: 108-24-7
acetic anhydride

: 1450733-46-6
(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 1450733-37-5
(S)-1-(p-nitrobenzyl)-2,2-dimethoxyethan-1-amine

: 1450733-46-6
(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018

Reference yield:

: 1450733-36-4
(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

: 1450733-46-6
(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With piperidine; palladium 10% on activated carbon; hydrogen; triethylamine; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.06.018