(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: (S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 1450733-36-4
• Molecular Formula: C₂₆H₂₆N₂O₆
• Molecular Weight: 462.502
• Mol file: 1450733-36-4.mol

Synonyms:(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of (S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about (S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (S)-(1-(p-nitrobenzyl)-2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester (948316-19-6) → (S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester (1450733-36-4)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.06.018

Reference yield: 79.0%

(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester (1450733-36-4) → (S)-1-(p-nitrobenzyl)-2,2-dimethoxyethan-1-amine (1450733-37-5)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

DOI:10.1016/j.bmc.2013.06.018

Reference yield:

(S)-(1-(p-nitrobenzyl)-2,2-dimethoxyethyl)carbamic acid 9H-fluoren-9-ylmethyl ester (1450733-36-4) → (S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea (1450733-57-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: piperidine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

2.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.1: methyl iodide / acetonitrile / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

6.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

With piperidine; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; triethylamine; sodium iodide; methyl iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmc.2013.06.018

upstream raw materials:

methanol

(S)-(1-(p-nitrobenzyl)-2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

Downstream raw materials:

(S)-1-benzyl-3-(1-(4-acetamidobenzyl)-2-oxoethyl)-1-piperidin-1-ylurea

(S)-1-(p-nitrobenzyl)-2,2-dimethoxyethan-1-amine

(S)-1-benzyl-3-(1-(4-nitrobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea

(S)-1-benzyl-3-(1-(4-aminobenzyl)-2,2-dimethoxyethyl)-1-piperidin-1-ylurea