3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol

Base Information

• Chemical Name: 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol
• CAS No.: 98008-60-7
• Molecular Formula: C₃₀H₃₆O₅
• Molecular Weight: 476.613
• Mol file: 98008-60-7.mol

Synonyms:3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol

Chemical Property of 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol

There total 6 articles about 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl chloride (98-88-4) + Acetic acid (7R,8R,9S,13S,14S,17S)-3-hydroxy-7-(3-hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester → 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol (98008-60-7)

Guidance literature:

With sodium hydroxide; In acetone; at 0 ℃;

DOI:10.1016/0039-128X(89)90076-7

Reference yield:

6-dehydro-19-nortestosterone acetate (2590-41-2) → 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol (98008-60-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 46 percent / Mg, CuI / tetrahydrofuran

2: 1) aq. AcOH, 2) pyridine / 1) THF, 50 deg C, 2) r.t.

3: CuBr₂, LiBr / acetonitrile / Heating

4: aq. 1N NaOH / methanol / Ambient temperature

5: aq. 1 N NaOH / acetone / 0 °C

With pyridine; sodium hydroxide; copper(l) iodide; magnesium; acetic acid; lithium bromide; copper(ll) bromide; In tetrahydrofuran; methanol; acetone; acetonitrile;

DOI:10.1016/0039-128X(89)90076-7

Reference yield:

Acetic acid (7R,8R,9S,13S,14S,17S)-7-(3-acetoxy-propyl)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester (98008-22-1) → 3-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propanol (98008-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. 1N NaOH / methanol / Ambient temperature

2: aq. 1 N NaOH / acetone / 0 °C

With sodium hydroxide; In methanol; acetone;

DOI:10.1016/0039-128X(89)90076-7

upstream raw materials:

benzoyl chloride

6-dehydro-19-nortestosterone acetate

Acetic acid (7R,8R,9S,10R,13S,14S,17S)-7-(3-acetoxy-propyl)-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester

Acetic acid (7R,8R,9S,13S,14S,17S)-7-(3-acetoxy-propyl)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Downstream raw materials:

Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pentanoate

Ethyl-5-(17β-acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)pent-2-enoate

3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionic acid

3-(17β-Acetoxy-3-benzoyloxyestra-1,3,5(10)-trien-7α-yl)propionaldehyde