4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

Base Information

Chemical Name:4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide
CAS No.:908306-44-5
Molecular Formula:C₂₄H₂₀ClFN₄O₃
Molecular Weight:466.899
Hs Code.:

Synonyms:4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

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Chemical Property of 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

Chemical Property:

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Technology Process of 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

There total 2 articles about 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908306-43-4
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methyl ester

: O-dimethylhydroxylamine hydrochloride

: 908306-44-5
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

Guidance literature:: With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 908306-43-4
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 908306-44-5
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.833333h; Product distribution / selectivity;

Reference yield:

: 908306-44-5
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide

: 16466-97-0,13254-27-8
1-propynylmagnesium bromide

: 908306-45-6
4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6-(1-oxo-2-butyn-1-yl)quinazoline

Guidance literature:: 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-quinazoline-6-carboxylic acid methoxy methyl amide; 1-propynylmagnesium bromide; In tetrahydrofuran; at 55 ℃; for 3h; Industry scale;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 - 5 ℃; for 0.5h; pH=3.5; Product distribution / selectivity;