dimethyl 2-(2-bromophenyl)-2-methylmalonate

Base Information

• Chemical Name: dimethyl 2-(2-bromophenyl)-2-methylmalonate
• CAS No.: 1069114-65-3
• Molecular Formula: C₁₂H₁₃BrO₄
• Molecular Weight: 301.137
• Mol file: 1069114-65-3.mol

Synonyms:dimethyl 2-(2-bromophenyl)-2-methylmalonate

Chemical Property of dimethyl 2-(2-bromophenyl)-2-methylmalonate

Chemical Property:

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Technology Process of dimethyl 2-(2-bromophenyl)-2-methylmalonate

There total 1 articles about dimethyl 2-(2-bromophenyl)-2-methylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

dimethyl 2-(2-bromophenyl)malonate (1069114-64-2) + methyl iodide (74-88-4) → dimethyl 2-(2-bromophenyl)-2-methylmalonate (1069114-65-3)

Guidance literature:

dimethyl 2-(2-bromophenyl)malonate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ja805598s

Reference yield: 61.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + dimethyl 2-(2-bromophenyl)-2-methylmalonate (1069114-65-3) → dimethyl 2-((trimethylsilyl)methyl)-2-(2-(trimethylsilyl)phenyl)malonate

Guidance literature:

With palladium diacetate; potassium carbonate; tri-p-tolylphosphite; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Schlenk technique; Cooling with liquid nitrogen;

DOI:10.1002/anie.201800330

Reference yield:

dimethyl 2-(2-bromophenyl)-2-methylmalonate (1069114-65-3) → C10H13BrO2

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jacs.6b02867

upstream raw materials:

dimethyl 2-(2-bromophenyl)malonate

methyl iodide