2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one
CAS No.:1386350-29-3
Molecular Formula:C₂₂H₂₄O₅
Molecular Weight:368.43
Hs Code.:

Synonyms:2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

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Chemical Property of 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

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Technology Process of 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

There total 14 articles about 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 63286-36-2
2-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-2-(phenylsulfonyl)ethanone

: 74-88-4
methyl iodide

: 1386350-29-3
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

Guidance literature:: With potassium carbonate; In acetone; for 12h; Reflux;
DOI:10.1016/j.ejmech.2019.02.014

Reference yield: 48.0%

: 1386351-93-4
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2Hchromen-6-yl)ethan-1-ol

: 1386350-29-3
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1h;

Reference yield:

: 108-46-3
recorcinol

: 1386350-29-3
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; nitric acid / chloroform / 1 h

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride / acetonitrile / 1.17 h / 0 °C

2.2: 0 °C

3.1: N,N-diethylaniline / 130 °C

4.1: potassium carbonate / acetone / 55 - 60 °C

5.1: tin(II) chloride dihdyrate / ethanol / 1 h / Reflux

6.1: hydrogen bromide / water / 0.17 h / 0 °C

6.2: 65 °C

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

7.2: 0.5 h / -78 - 20 °C

8.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

With n-butyllithium; tin(II) chloride dihdyrate; hydrogen bromide; nitric acid; potassium carbonate; Dess-Martin periodane; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; water; acetone; acetonitrile;
DOI:10.1021/jm301488q