tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate
CAS No.:851577-50-9
Molecular Formula:C₂₅H₃₃N₃O₂
Molecular Weight:407.556
Hs Code.:

Synonyms:tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

There total 10 articles about tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 851577-49-6
tert-butyl {[5-(hydroxymethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

: 151-50-8
potassium cyanide

: 851577-50-9
tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: tert-butyl {[5-(hydroxymethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

potassium cyanide; In dimethyl sulfoxide; at 60 ℃; for 0.5h;

Reference yield:

: 851579-82-3
[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

: 7677-24-9
trimethylsilyl cyanide

: 851577-50-9
tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 20 ℃; for 1h;

Reference yield:

: C₁₉H₂₆N₂O

: 851577-50-9
tert-butyl {[5-(cyanomethyl)-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran; acetonitrile / 1 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1016/j.bmc.2010.11.038