[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

Base Information

Chemical Name:[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate
CAS No.:851579-82-3
Molecular Formula:C₂₅H₃₆N₂O₅S
Molecular Weight:476.637
Hs Code.:

Synonyms:[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

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Chemical Property of [5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

Chemical Property:

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Technology Process of [5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

There total 6 articles about [5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 907611-08-9
5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile

: 851579-82-3
[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 4 h / 80 °C

2.1: nitric acid / 1,4-dioxane / 0.75 h / 75 - 80 °C

3.1: ammonia; hydrogen / methanol; water / 5 h / 40 °C / 3750.38 Torr / Sealed tube

4.1: diisobutylaluminium hydride / toluene / -78 - 0 °C

4.2: 0 - 20 °C

5.1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With ammonia; hydrogen; nitric acid; diisobutylaluminium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; acetone; toluene;
DOI:10.1016/j.bmc.2010.11.038

Reference yield:

: 851577-38-3
methyl 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxylate

: 851579-82-3
[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene / -78 - 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With diisobutylaluminium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; acetone; toluene;
DOI:10.1016/j.bmc.2010.11.038

Reference yield:

: 64373-43-9
5-methyl-3-oxo-hexanenitrile

: 851579-82-3
[5-([(tert-butoxycarbonyl)amino]methyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine; acetic acid / toluene / 5 h / Reflux

2.1: methanol / 4 h / 80 °C

3.1: nitric acid / 1,4-dioxane / 0.75 h / 75 - 80 °C

4.1: ammonia; hydrogen / methanol; water / 5 h / 40 °C / 3750.38 Torr / Sealed tube

5.1: diisobutylaluminium hydride / toluene / -78 - 0 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide / water; ethyl acetate; acetone; toluene / 0.5 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

With piperidine; ammonia; hydrogen; nitric acid; diisobutylaluminium hydride; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate; acetone; toluene; 1.1: Knoevenagel condensation;
DOI:10.1016/j.bmc.2010.11.038