3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

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Chemical Name:3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide
CAS No.:935840-37-2
Molecular Formula:C₁₈H₂₄Cl₂N₂O₂
Molecular Weight:371.307
Hs Code.:

Synonyms:3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

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Chemical Property of 3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

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Technology Process of 3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

There total 1 articles about 3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 935840-98-5
1-(2,3-dichlorobenzyl)pyrrolidine

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 506-59-2
N,N-dimethylammonium chloride

: 935840-37-2
3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

Guidance literature:: 1-(2,3-dichlorobenzyl)pyrrolidine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -100 - -85 ℃; for 0.583333h;

3-oxocyclobutanecarboxylic acid; In tetrahydrofuran; cyclohexane; at -100 - 0 ℃; for 0.533333h;

N,N-dimethylammonium chloride; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield: 90.0%

: 935840-37-2
3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide

: 3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-fluoro-N,N-dimethylcyclobutanecarboxamide

Guidance literature:: 3-[2,3-dichloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxy-N,N-dimethylcyclobutanecarboxamide; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -75 ℃; for 1.16667h;

With sodium carbonate; In dichloromethane; at 0 ℃;