(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

Base Information

Chemical Name:(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde
CAS No.:1431860-70-6
Molecular Formula:C₂₅H₃₄O₂S₂Si
Molecular Weight:458.761
Hs Code.:

Synonyms:(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

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Chemical Property of (2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

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Technology Process of (2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

There total 4 articles about (2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1431860-90-0
C₂₅H₃₆O₂S₂Si

: 1431860-70-6
(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

Guidance literature:: C₂₅H₃₆O₂S₂Si; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo4002382

Reference yield:

: 1431860-66-0
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}ethanol

: 1431860-70-6
(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: acetic acid / tetrahydrofuran; water / 22 h / 42 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With 1H-imidazole; dmap; oxalyl dichloride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jo4002382

Reference yield:

: 1431860-68-2
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

: 1431860-70-6
(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran; water / 22 h / 42 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo4002382