2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

Base Information

Chemical Name:2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane
CAS No.:1431860-68-2
Molecular Formula:C₃₁H₅₀O₂S₂Si₂
Molecular Weight:575.04
Hs Code.:

Synonyms:2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

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Chemical Property of 2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

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Technology Process of 2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

There total 6 articles about 2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1431860-66-0
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}ethanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1431860-68-2
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jo4002382

Reference yield:

: 105859-45-8
(S)-3-(tert-butyldimethylsilyloxy)-2-methylpropan-1-ol

: 1431860-68-2
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

Guidance literature:: Multi-step reaction with 4 steps

1.1: Inert atmosphere

2.1: boron trifluoride diethyl etherate / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 20 °C / Inert atmosphere

3.2: 3.5 h / -78 - 20 °C / Inert atmosphere

4.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane; 1.1: |Swern Oxidation;
DOI:10.1021/jo4002382

Reference yield:

: 97826-89-6
(2R)-3-(tert-butyldimethylsilyloxy)-2-methylpropanal

: 1431860-68-2
2-{2-[(1R)-2-(tert-butyldimethylsilanyloxy)-1-methylethyl]-[1,3]dithian-2-yl}-1-(tert-butyldiphenylsilanyloxy)ethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / 20 °C / Inert atmosphere

2.2: 3.5 h / -78 - 20 °C / Inert atmosphere

3.1: dmap; 1H-imidazole / dichloromethane / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo4002382