(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

Base Information

Chemical Name:(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one
CAS No.:1431860-73-9
Molecular Formula:C₂₆H₃₆O₂S₂Si
Molecular Weight:472.788
Hs Code.:

Synonyms:(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

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Chemical Property of (3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

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Technology Process of (3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

There total 6 articles about (3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: C₂₆H₃₈O₂S₂Si

: 1431860-73-9
(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

Guidance literature:: C₂₆H₃₈O₂S₂Si; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.75h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo4002382

Reference yield:

: 1431860-90-0
C₂₅H₃₆O₂S₂Si

: 1431860-73-9
(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/jo4002382

Reference yield:

: 1431860-70-6
(2R)-2-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}propionaldehyde

: 1431860-73-9
(3R)-3-{2-[2-(tert-butyldiphenylsilanyloxy)ethyl]-[1,3]dithian-2-yl}butan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; diethyl ether; dichloromethane; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo4002382