3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid
CAS No.:1445787-52-9
Molecular Formula:C₂₈H₂₆FN₅O₃
Molecular Weight:499.545
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

There total 15 articles about 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1445790-97-5
methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

: 1445787-52-9
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 30 ℃; for 16h;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1445787-52-9
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1 h / 100 °C

2.1: diphenylether / 16 h / 240 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

4.1: trichlorophosphate / 3 h / 110 °C

4.2: Cooling with ice

5.1: acetic acid / 2 h / 20 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere

6.2: 0.5 h / 110 °C / Inert atmosphere

7.1: potassium hydroxide / tetrahydrofuran; methanol / 16 h / 30 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; acetic acid; bis(pinacol)diborane; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445787-52-9
3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 2 h / 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere

2.2: 0.5 h / 110 °C / Inert atmosphere

3.1: potassium hydroxide / tetrahydrofuran; methanol / 16 h / 30 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; acetic acid; bis(pinacol)diborane; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol;