methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate
CAS No.:1445790-97-5
Molecular Formula:C₂₉H₂₈FN₅O₃
Molecular Weight:513.571
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

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Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

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Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

There total 14 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1445790-75-9
methyl 3-((7-bromo-3-carbamoyl-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

: 69696-37-3
5-bromo-2,4-dimethylpyrimidine

: 1445790-97-5
methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

Guidance literature:: methyl 3-((7-bromo-3-carbamoyl-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; bis(pinacol)diborane; In 1,4-dioxane; at 110 ℃; for 0.5h; Inert atmosphere;

5-bromo-2,4-dimethylpyrimidine; With caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1445790-97-5
methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1 h / 100 °C

2.1: diphenylether / 16 h / 240 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

4.1: trichlorophosphate / 3 h / 110 °C

4.2: Cooling with ice

5.1: acetic acid / 2 h / 20 °C

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere

6.2: 0.5 h / 110 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; acetic acid; bis(pinacol)diborane; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445790-97-5
methyl 3-((3-carbamoyl-7-(2,4-dimethylpyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 2 h / 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere

2.2: 0.5 h / 110 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; acetic acid; bis(pinacol)diborane; In 1,4-dioxane;