(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Base Information

Chemical Name:(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]
CAS No.:213924-50-6
Molecular Formula:C₂₂H₂₈N₂O₂S
Molecular Weight:384.543
Hs Code.:

Synonyms:(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Suppliers and Price of (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

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Chemical Property of (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Chemical Property:

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Technology Process of (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

There total 6 articles about (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 98-59-9
p-toluenesulfonyl chloride

: 213924-49-3
(+)-6',6'-dimethylspiro(tetralin-1,2'-piperazine)

: 213924-50-6
(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jo9808831

Reference yield:

: 79817-66-6
1-nitro-1,2,3,4-tetrahydronaphthalene

: 213924-50-6
(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / H₂O / 0.75 h / 15 °C

2: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

3: 96 percent / NaCN, BnEt₃NCl, NaOH / CH₂Cl₂; H₂O / 10 °C

4: 546 mg / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 6 h

5: 79 percent / H₂ / Pearlman' catalyst / methanol / 6 h / 2585.7 Torr

6: 95 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; triethylamine; palladium hydroxide - carbon; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo9808831

Reference yield:

: 213924-45-9
1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

: 213924-50-6
(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaCN, BnEt₃NCl, NaOH / CH₂Cl₂; H₂O / 10 °C

2: 546 mg / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 6 h

3: 79 percent / H₂ / Pearlman' catalyst / methanol / 6 h / 2585.7 Torr

4: 95 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; triethylamine; palladium hydroxide - carbon; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo9808831