1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

Base Information

• Chemical Name: 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine
• CAS No.: 213924-45-9
• Molecular Formula: C₁₉H₂₄N₂
• Molecular Weight: 280.413

Synonyms:1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

Chemical Property of 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

Chemical Property:

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Technology Process of 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

There total 3 articles about 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine (213924-44-8) → 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine (213924-45-9)

Guidance literature:

With hydrogen; nickel; In ethanol; at 50 ℃; for 4h; under 25857.4 Torr;

DOI:10.1021/jo9808831

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine (213924-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / H₂O / 0.75 h / 15 °C

2: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

With hydrogen; nickel; In ethanol; water;

DOI:10.1021/jo9808831

Reference yield:

1-nitro-1,2,3,4-tetrahydronaphthalene (79817-66-6) → 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine (213924-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / H₂O / 0.75 h / 15 °C

2: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

With hydrogen; nickel; In ethanol; water;

DOI:10.1021/jo9808831

upstream raw materials:

(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

(S)-1-phenyl-ethylamine

1-nitro-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

3',3'-dimethyl-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

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