Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

Base Information

Chemical Name:Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester
CAS No.:834916-79-9
Molecular Formula:C₅₇H₁₀₂O₁₃SSi₃
Molecular Weight:1111.75
Hs Code.:

Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

Synonyms:Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

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Chemical Property of Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

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Technology Process of Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

There total 12 articles about Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: (E)-(2R,3S,10S,11S)-11-(4-Methoxy-benzyloxymethoxy)-8-methoxymethoxymethyl-2,3-dimethyl-11-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-10-triethylsilanyloxy-1-triisopropylsilanyloxy-undec-8-en-5-ol

: 834916-79-9
Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.200461802

Reference yield:

: 994-30-9
triethylsilyl chloride

: 834916-79-9
Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / tetrahydrofuran / 40 °C

2: DIPEA; n-Bu₄NBr / CH₂Cl₂ / Heating

3: 89 percent / DIBAL-H / tetrahydrofuran / -78 °C

4: 95 percent / DIPEA; n-Bu₄NBr / 1,2-dichloro-ethane / 20 °C

5: tetrahydrofuran / 20 °C

6: aq. H₂O₂; NaOH / 0 - 20 °C

7: 84 percent / SO₃*py; Et₃N; DMSO / CH₂Cl₂ / 20 °C

8: 85 percent / tetrahydrofuran / 0 °C

9: Et₃N / CH₂Cl₂ / 0 °C

With sodium hydroxide; pyridine-SO₃ complex; tetrabutylammomium bromide; dihydrogen peroxide; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/anie.200461802

Reference yield:

: 3006-41-5,20771-09-9,25152-90-3,97232-16-1,104022-77-7,113566-67-9,113566-68-0
4,6-O-benzylidene-D-glucose

: 834916-79-9
Methanesulfonic acid (E)-(6S,7S)-1-((2S,3R)-2,3-dimethyl-4-triisopropylsilanyloxy-butyl)-7-(4-methoxy-benzyloxymethoxy)-4-methoxymethoxymethyl-7-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-6-triethylsilanyloxy-hept-4-enyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: tetrahydrofuran / Heating

2: Et₃N / tetrahydrofuran / 40 °C

3: DIPEA; n-Bu₄NBr / CH₂Cl₂ / Heating

4: 89 percent / DIBAL-H / tetrahydrofuran / -78 °C

5: 95 percent / DIPEA; n-Bu₄NBr / 1,2-dichloro-ethane / 20 °C

6: tetrahydrofuran / 20 °C

7: aq. H₂O₂; NaOH / 0 - 20 °C

8: 84 percent / SO₃*py; Et₃N; DMSO / CH₂Cl₂ / 20 °C

9: 85 percent / tetrahydrofuran / 0 °C

10: Et₃N / CH₂Cl₂ / 0 °C

With sodium hydroxide; pyridine-SO₃ complex; tetrabutylammomium bromide; dihydrogen peroxide; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: Wittig reaction;
DOI:10.1002/anie.200461802