N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide

Base Information

• Chemical Name: N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide
• CAS No.: 1570232-36-8
• Molecular Formula: C₂₄H₂₆N₂O₂
• Molecular Weight: 374.483
• Mol file: 1570232-36-8.mol

Synonyms:N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide

Chemical Property of N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide

There total 6 articles about N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzophenone (119-61-9) + N-(pyridin-3-ylmethyl)pivalamide (109902-24-1) → N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide (1570232-36-8)

Guidance literature:

N-(pyridin-3-ylmethyl)pivalamide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 2h; Inert atmosphere;

benzophenone; In tetrahydrofuran; pentane; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0033-1338547

Reference yield: 20.0%

benzophenone (119-61-9) + N-(pyridin-3-ylmethyl)pivalamide (109902-24-1) + tert.-butyl lithium (594-19-4) → N-[(4-tert-butylpyridin-3-yl)methyl]pivalamide (1570232-40-4) + N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide (1570232-36-8)

Guidance literature:

N-(pyridin-3-ylmethyl)pivalamide; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 2h; Inert atmosphere;

benzophenone; In tetrahydrofuran; pentane; at -50 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0033-1338547

Reference yield: 6.0%

n-butyllithium (109-72-8,29786-93-4) + benzophenone (119-61-9) + N-(pyridin-3-ylmethyl)pivalamide (109902-24-1) → N-[(4-butylpyridin-3-yl)methyl]pivalamide (1570232-30-2) + N-[2-hydroxy-2,2-diphenyl-1-(pyridine-3-yl)ethyl]pivalamide (1570232-33-5) + N-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}pivalamide (1570232-36-8)

Guidance literature:

n-butyllithium; N-(pyridin-3-ylmethyl)pivalamide; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

benzophenone; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Temperature; Inert atmosphere;

DOI:10.1055/s-0033-1338547

upstream raw materials:

pivaloyl chloride

3-Aminomethylpyridine

n-butyllithium

benzophenone