(R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 1258740-37-2
• Molecular Formula: C₁₈H₁₉NO₄S
• Molecular Weight: 345.419
• Mol file: 1258740-37-2.mol

Synonyms:(R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide

Chemical Property of (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide

There total 3 articles about (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid (1258740-26-9) → 6-methoxy-1-naphthol (22604-07-5) + (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide (1258740-37-2)

Guidance literature:

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid; With phosphorus pentachloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With tin(IV) chloride; In dichloromethane; at 0 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.025

Reference yield: 27.0%

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid (1258740-26-9) → 6-methoxy-1-naphthol (22604-07-5) + (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide (1258740-37-2) + toluene-4-sulfonamide (70-55-3)

Guidance literature:

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid; With phosphorus pentachloride; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With tin(IV) chloride; In dichloromethane; at 20 ℃; for 3h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.025

Reference yield: 23.0%

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid (1258740-26-9) → 8-methoxy-naphthalen-1-ol (3588-75-8) + 6-methoxy-1-naphthol (22604-07-5) + (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide (1258740-37-2)

Guidance literature:

With trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; for 0.5h; regioselective reaction; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.tet.2010.09.025

upstream raw materials:

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

Downstream raw materials:

(S)-N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide