(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

Base Information

Chemical Name:(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane
CAS No.:1403558-99-5
Molecular Formula:C₁₉H₂₂O₆
Molecular Weight:346.38
Hs Code.:

Synonyms:(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

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Chemical Property of (1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

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Technology Process of (1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

There total 4 articles about (1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1403558-98-4
(1RS)-1-(3,4,5-trimethoxy-2-(5-methoxyfurane-2-yl)phenyl)ethanol

: 106-96-7
propargyl bromide

: 1403558-99-5
(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

Guidance literature:: (1RS)-1-(3,4,5-trimethoxy-2-(5-methoxyfurane-2-yl)phenyl)ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201200677

Reference yield:

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 1403558-99-5
(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

Guidance literature:: Multi-step reaction with 4 steps

1.1: iodine; silver trifluoroacetate / chloroform / 5 h / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / Inert atmosphere; Reflux

3.1: sodium tetrahydroborate / ethanol / 4 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.2: 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; silver trifluoroacetate; sodium hydride; In ethanol; chloroform; N,N-dimethyl-formamide; toluene; 2.1: |Stille Cross Coupling;
DOI:10.1002/ejoc.201200677

Reference yield:

: 1403558-97-3
1-(3,4,5-trimethoxy-2-(5-methoxyfurane-2-yl)phenyl)ethanone

: 1403558-99-5
(1′′RS)-2-methoxy-5-(2,3,4-trimethoxy-6-(1-(prop-2-ynyloxy)ethyl)phenyl)-furane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201200677