Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate

Base Information

• Chemical Name: Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate
• CAS No.: 755-73-7
• Molecular Formula: C5H6F4O3
• Molecular Weight: 190.094
• Hs Code.: 2918990090
• European Community (EC) Number: 212-048-1
• DSSTox Substance ID: DTXSID6061074
• Nikkaji Number: J193.115F
• Wikidata: Q72490981
• Mol file: 755-73-7.mol

Synonyms:755-73-7;Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate;Methyl 2,2,3,3-tetrafluoro-3-methoxypropanoate;Methyl 3-methoxyperfluoropropanoate;Propanoic acid, 2,2,3,3-tetrafluoro-3-methoxy-, methyl ester;Methyl 3-methoxytetrafluoropropanoate;methyl 3-methoxytetrafluoropropionate;Methyl 2,2,3,3-tetrafluoro-3-methoxy-propanoate;EINECS 212-048-1;Propanoic acid,2,2,3,3-tetrafluoro-3-methoxy-, methyl ester;MFCD01757080;METHYL 2,2,3,3-TETRAFLUORO-3-(METHOXY)PROPIONATE;2,2,3,3-Tetrafluoro-3-methoxypropanoic acid, methyl ester;C5H6F4O3;SCHEMBL1700780;DTXSID6061074;AMY6838;C5-H6-F4-O3;Methyl 3-Tetrafluoromethoxypropionate;AKOS005063665;AS-82265;LS-121597;3-Methoxyperfluoropropionic acid methyl ester;FT-0752047;F87724;Metyl 2,2,3,3 tetrafluoro-3 methoxypropionate;methyl 3-methoxy-2,2,3,3-tetrafluoropropionate;W-104392

Chemical Property of Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate

Chemical Property:

• Vapor Pressure: 2.7mmHg at 25°C
• Refractive Index: 1.3327
• Boiling Point: 157.8 °C at 760 mmHg
• Flash Point: 48.5 °C
• PSA: 35.53000
• Density: 1.331 g/cm³
• LogP: 1.03390
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 190.02530670
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-methoxytetrafluoropropionate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(C(OC)(F)F)(F)F
• Uses: Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate is a useful research chemical. Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate belongs to carboxylate organic compounds and can be used as an intermediate in organic synthesis.

Technology Process of Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate

There total 4 articles about Methyl 2,2,3,3-tetrafluoro-3-methoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-Methoxytetrafluoropropionyl fluoride (2794-15-2) → methyl 3-methoxy-2,2,3,3-tetrafluoropropionate (755-73-7)

Guidance literature:

With sodium fluoride;

DOI:10.1021/ja00881a017

Reference yield:

methanol (67-56-1) + 3-methoxycarbonyl-2,2,3,3-tetrafluoropropanoic acid (356-33-2) → methyl 3-methoxy-2,2,3,3-tetrafluoropropionate (755-73-7)

Guidance literature:

With sodium methylate; In acetonitrile; (anodic oxidation);

Reference yield:

→ methyl 3-methoxy-2,2,3,3-tetrafluoropropionate (755-73-7)

Guidance literature:

upstream raw materials:

methanol

3-Methoxytetrafluoropropionyl fluoride

3-methoxycarbonyl-2,2,3,3-tetrafluoropropanoic acid

Downstream raw materials:

dimethyl 2,2-difluoro-malonate

Methyl fluoroformyldifluoroacetate