4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

Base Information

Chemical Name:4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid
CAS No.:1428527-86-9
Molecular Formula:C₁₉H₁₅N₄O₄P
Molecular Weight:394.326
Hs Code.:

Synonyms:4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

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Chemical Property of 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

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Technology Process of 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

There total 14 articles about 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428527-85-8
ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

: 1428527-86-9
4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; for 1h; Reflux;

Reference yield:

: 1428527-77-8
5-ethynyl-4-(4-methoxybenzyloxy)-2-(pyridin-2-yl)pyrimidine

: 1428527-86-9
4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 12 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 10 h / 20 °C

3: sodium hydroxide / 1,4-dioxane; water / 1 h / Reflux

With triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 226990-49-4
methyl 2-(methoxymethylene)-4-(trimethylsilyl)but-3-ynoate

: 1428527-86-9
4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / methanol / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 80 °C

3: triethylamine / tetrahydrofuran / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 10 h / 20 °C

5: sodium hydroxide / 1,4-dioxane; water / 1 h / Reflux

With triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;