ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

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Chemical Name:ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate
CAS No.:1428527-85-8
Molecular Formula:C₂₁H₁₉N₄O₄P
Molecular Weight:422.38
Hs Code.:

Synonyms:ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

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Chemical Property of ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

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Technology Process of ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

There total 13 articles about ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1428527-84-7
ethyl 4-(5-(4-(4-methoxybenzyloxy)-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

: 1428527-85-8
ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 10h;

Reference yield:

: 1428527-77-8
5-ethynyl-4-(4-methoxybenzyloxy)-2-(pyridin-2-yl)pyrimidine

: 1428527-85-8
ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 12 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 10 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 226990-49-4
methyl 2-(methoxymethylene)-4-(trimethylsilyl)but-3-ynoate

: 1428527-85-8
ethyl 4-(5-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-yl)isoxazol-3-yl)phenyl(methyl)phosphinate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 80 °C

3: triethylamine / tetrahydrofuran / 12 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 10 h / 20 °C

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;