4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine
CAS No.:1616434-24-2
Molecular Formula:C₁₄H₁₇Cl₂N₃
Molecular Weight:298.215
Hs Code.:

Synonyms:4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

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Chemical Property of 4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

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Technology Process of 4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

There total 15 articles about 4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1658500-49-2
2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

: 122-51-0
orthoformic acid triethyl ester

: 1616434-24-2
4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: With hydrogenchloride; acetic anhydride; In 1,4-dioxane; at 90 ℃; for 2h;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616434-24-2
4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / tetrahydrofuran / 2 h / 20 - 50 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux

3.1: chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: acetic anhydride; hydrogenchloride / 1,4-dioxane / 2 h / 90 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); acetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/acs.jmedchem.1c01524

Reference yield:

: 1235873-11-6
2,6-dichloro-3-iodopyridin-4-amine

: 1616434-24-2
4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

2: acetic anhydride; hydrogenchloride / 1,4-dioxane / 2 h / 90 °C

With hydrogenchloride; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); acetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/acs.jmedchem.1c01524