(1r,4r)-4-methylcyclohexanecarbaldehyde

Base Information

• Chemical Name: (1r,4r)-4-methylcyclohexanecarbaldehyde
• CAS No.: 7133-05-3
• Molecular Formula: C8H14O
• Molecular Weight: 126.199
• Mol file: 7133-05-3.mol

Synonyms:4-Methyl-cyclohexanecarbaldehyde;trans-4-methyl-cyclohexanecarbaldehyde;trans-4-methylcyclohexanecarbaldehyde;trans-4-Methl-cyclohexyl-methanal;

Chemical Property of (1r,4r)-4-methylcyclohexanecarbaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 2.01160

Purity/Quality:

95% ^*data from raw suppliers

(1r,4r)-4-Methylcyclohexane-1-carbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1r,4r)-4-methylcyclohexanecarbaldehyde

There total 9 articles about (1r,4r)-4-methylcyclohexanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(trans-4-methylcyclohexyl)methanol (3937-49-3) → trans-4-(methyl)cyclohexane-1-carbaldehyde (7133-05-3)

Guidance literature:

With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at -10 - 20 ℃; for 16h;

Reference yield: 14.2%

trans-1,4-dimethylcyclohexane (2207-04-7) → trans-4-(methyl)cyclohexane-1-carbaldehyde (7133-05-3) + (+-)-trans-2,5-dimethyl-cyclohexanone (66395-23-1)

Guidance literature:

With air; acetic acid; 2Pyr; zinc; In pyridine;

DOI:10.1016/S0040-4039(01)81400-3

Reference yield: 11.0%

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) + 1-methylcyclohexan-4-one (589-92-4) → trans-4-(methyl)cyclohexane-1-carbaldehyde (7133-05-3)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

1-methylcyclohexan-4-one; In tetrahydrofuran; hexane; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 90 ℃; for 3h;

DOI:10.1021/acs.orglett.0c00124

upstream raw materials:

trans-1,4-dimethylcyclohexane

trans-4-methylcyclohexanecarbonyl chloride

trans-4-methylcyclohexanecarboxylic acid

dimethyl 1,4-cyclohexane dicarboxylate

Downstream raw materials:

N-[(S)-cyano(trans-4-methylcyclohexyl)methyl]-(S)-4-methylbenzenesulfinamide

2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-[(1r,4S)-4-methylcyclohexyl]acetic acid