tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate

Base Information

• Chemical Name: tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate
• CAS No.: 1658500-48-1
• Molecular Formula: C₁₈H₂₇Cl₂N₃O₂
• Molecular Weight: 388.337
• Mol file: 1658500-48-1.mol

Synonyms:tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate

Chemical Property of tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate

Chemical Property:

• Boiling Point: 471.3±45.0 °C(Predicted)
• PKA: 10.96±0.70(Predicted)
• Density: 1.223±0.06 g/cm3(Predicted)

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate

There total 9 articles about tert-butyl (2,6-dichloro-3-((((1r,4r)-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-4-(methyl)cyclohexane-1-carbaldehyde (7133-05-3) + tert-butyl (3-amino-2,6-dichloropyridin-4-yl)carbamate (1616434-23-1) → tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (1658500-48-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield:

2,6-dichloro-3-nitropyridin-4-amine (2897-43-0) → tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (1658500-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -20 - 20 °C

2: iron; water / ethanol / 10 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With water; sodium tris(acetoxy)borohydride; iron; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate (1313726-52-1) → tert-butyl (2,6-dichloro-3-(((trans-4-methylcyclohexyl)methyl)amino)pyridin-4-yl)carbamate (1658500-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; water / ethanol / 10 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

With water; sodium tris(acetoxy)borohydride; iron; acetic acid; In ethanol; dichloromethane;

upstream raw materials:

2,6-dichloro-3-nitropyridin-4-amine

tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate

trans-4-(methyl)cyclohexane-1-carbaldehyde

tert-butyl (3-amino-2,6-dichloropyridin-4-yl)carbamate

Downstream raw materials:

2,6-dichloro-N³-((trans-4-methylcyclohexyl)methyl)pyridine-3,4-diamine

4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

2-bromo-4,6-dichloro-3-(((trans)-4-methylcyclohexyl)methyl)-3H-imidazo[4,5-c]pyridine

4,6-dichloro-3-[(trans-4-methylcyclohexyl)methyl]-2-[(3R)-3-phenylmorpholin-4-yl]-3H-imidazo[4,5-c]pyridine